Age-Dependent Sensitization of Cutaneous Nociceptors during Developmental Inflammation
نویسندگان
چکیده
منابع مشابه
Age-dependent sensitization of cutaneous nociceptors during developmental inflammation
BACKGROUND It is well-documented that neonates can experience pain after injury. However, the contribution of individual populations of sensory neurons to neonatal pain is not clearly understood. Here we characterized the functional response properties and neurochemical phenotypes of single primary afferents after injection of carrageenan into the hairy hindpaw skin using a neonatal ex vivo rec...
متن کاملUpregulation of P2Y1 in neonatal nociceptors regulates heat and mechanical sensitization during cutaneous inflammation
Abstract The upregulation of various channels and receptors classically linked to sensory transduction from the periphery tightly correspond with changes in the responsiveness of specific subpopulations of primary afferents to mechanical and heat stimulation of the skin at different ages. Previous reports in adults have suggested that the purinergic adenosine diphosphate receptor, P2Y1 can spec...
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Inflammation is a part of the body's natural response to tissue injury which initiates the healing process. Unfortunately, inflammation is frequently painful and leads to hypersensitivity to mechanical stimuli, which is difficult to treat clinically. While it is well established that altered sensory processing in the spinal cord contributes to mechanical hypersensitivity (central sensitization)...
متن کاملMechanical and heat sensitization of cutaneous nociceptors after peripheral inflammation in the rat.
Tissue injuries commonly cause an increase in pain sensitivity, so that normally painful stimuli become more painful (hyperalgesia), and those usually associated with nonnoxious sensations evoke pain (allodynia). The neural bases for these sensory phenomena have been explored most extensively using heat injuries and experimental arthritis as models. Heat sensitization of cutaneous nociceptors i...
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C-Fiber mechanoheat (C-MH) nociceptors from the saphenous nerve were studied, in control rats and in rats that underwent surgical sympathectomy. Intradermal injection, alone, of either norepinephrine (NE) or the calcium ionophore, A23187, did not affect mechanical threshold. The combination of A23187 and NE, however, significantly decreased mechanical threshold. In the presence of the alpha 2-a...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2014
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-10-34